Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase-deficient mice.

35 , 36 Our data confirm our earlier reports of significant astrogliosis and glutamine deficiency in aldh5a1‐deficient mice, and indicate a definite trend ( P = .08) toward glul deficiency suggesting that, in this mouse model of SSADHD astrogliosis may be responsible for central glutamine deficiency.

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