Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.

Comparison of GSEA data from 2 days after infection to 4 days after infection in untreated RMs show robust, highly significant positive enrichment in pathways comprised of genes for inflammatory responses, TNF-α and IL-6 signaling, and neutrophil and granulocyte function—indicating that, in the absence of baricitinib, expression of these genes continues to increase ( Figure 3 B).

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