A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.

Furthermore, we observed an increased correlation with inflammatory AMP-AD co-expression modules after 4 months of age, where older mice at (6–12 months) showed a highly significant overlap with human immune modules in the cerebellum, superior temporal gyrus and inferior frontal gyrus ( p < 0.05, Pearson’s correlation coefficient > 0.35).

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