Regulation of Metabolism by an Ensemble of Different Ion Channel Types: Excitation-Secretion Coupling Mechanisms of Adipokinetic Hormone Producing Cells in <i>Drosophila</i>.

Genetic knockdown of three genes ( Ca-Beta , Sur , and sei ), in AKH producing cells caused highly significant changes ( P < 0.001) in both male and female lifespan, and knockdown of six other genes ( Shaw , cac , Ih , NaCP60E , stj , and TASK6 ) caused significant changes ( P < 0.05) in only female lifespan.

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The finding of seizure channels as a regulator of AKH secretion suggests that there may be significant parallels in the regulatory components of glucagon secretion and AKH cells.

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