Identification of Intrinsic Drug Resistance and Its Biomarkers in High-Throughput Pharmacogenomic and CRISPR Screens.

Another limitation we observed is that UNRES cell lines with a very low adjusted pvalue “pull” other sensitive cell lines—e.g., the real UNRES case where both NCI-H1975 and NCI-H1650 are resistant to gefitinib was highly significant, but another UNRES case with these two cell lines along with PC-14 (a classical EGFR mutant cell line that is known to be sensitive to gefitinib) was also falsely detected as significant ( Table S5 ).

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