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ctDNA facilitated the diagnosis of a patient with synchronous urothelial carcinoma and non-small cell lung cancer: case report.

Ann Transl Med · 2020 · PMC7661894 · PMID 33209903

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an increasing trendno p-value reported
Epidemiological studies indicate that the prevalence of multiple primary cancer is approximately 2–17%, with an increasing trend in recent years ( 6 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.