A recent study showed that efavirenz concentrations remained therapeutic in adult patients receiving double-dosed rifampicin as part of their TB treatment, despite a slight trend towards lower efavirenz concentrations. 185 However, these findings cannot be extrapolated to children or other ARVs due to differences in enzyme activity and different metabolic pathways.
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Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review.
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