The Role of <i>CASC2</i> and <i>miR-21</i> Interplay in Glioma Malignancy and Patient Outcome.

When all samples were divided into IDH1 gene mutated ( IDH1mut , n = 18) and IDH1 wild-type ( IDH1wt , n = 78) gliomas, we observed a tendency of lower expression of CASC2 in IDH1wt ( p = 0.053) and highly significant relationship between higher miR-21 expression and IDH1wt gliomas ( p < 0.0001) ( Figure 2 A,B). 2.3.

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