Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations.

Glycerophospholipid significantly decreased in rat plasma and showed a decreasing trend in human plasma post-CA.

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Humans and rats have a similar overall distribution in altered metabolites, such that greater than 75% metabolites measured are either increased, or show an increasing trend, measured in terms of fold change from control.

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