Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study.

When analyzing the relationship between each baseline covariate and post-operatives HMGB1 levels (Table 4 ), no association was found statistically significant, except for baseline HMGB1 levels ( p < 0.0001), indicating that patients with higher level before surgery mostly kept high levels after surgery. Discussion Summary of findings The present study indicates that at least 75% of non-cardiac surgical patients experienced a decrease in MMSE levels 6 weeks postoperatively with a highly significant mean drop of 2.1 ± 3.1 points ( p = 0.0006).

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