The frequency of combined IFITM3 haplotype involving the reference alleles of both rs12252 and rs34481144 is in line with COVID-19 standardized mortality ratio of ethnic groups in England.

In the case where heterozygote rs12252:AG (37/80 or 46% abundance) is expected to behave similarly to homozygote rs12252:AA (19%), so that homozygote rs12252:GG (35%) appears as the risk genotype, then a chi-square statistic would report a non-significant p = 0.36, when q (frequency of rs12252:G) = 0.54 and q 2 = 0.29 according to Hardy-Weinberg equilibrium, or borderline significant p = 0.04, when q (frequency of rs12252:G) = 0.47, with q 2 = 0.22.

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In both cases the correlations proved highly significant.

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