RNA-seq accuracy and reproducibility for the mapping and quantification of influenza defective viral genomes.

This highly significant enrichment strongly suggests that, in addition to a genetic control exerted through the viral polymerase subunits ( Fodor et al. 2003 ; Vasilijevic et al. 2017 ; and this study) and other viral proteins ( Odagiri et al. 1994 ; Perez-Cidoncha et al. 2014 ), the presence of A/T-rich direct repeats in the viral genome may direct polymerase jumps and control the production of deletion DVGs.

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