Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome.

Diabetes Metab Syndr Obes · 2020 · PMC7670174 · PMID 33209044

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closest p · 0.0× alpha

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highly significantP < 1×10 −6actually significant

Results Meta-analysis of 9953 females combining discovery (N = 4658) and replication (N = 5295) stages detected four (rs11162584, rs6760543, rs828104, rs56137030), six (rs139702234, rs2341967, rs73059848, rs5020945, rs550532151, rs61971548), and two genetic variants (rs7722169, rs7206790) suggesting a highly significant association ( P < 1×10 −6 ) with BMI, WHR, and WC, respectively.

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