Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations.

When we applied these approaches on Clatot’s data (2017), we found that the interaction between wild-type Na v 1.5 channels is highly significant during activation and around the peak of macroscopic Na + current, but this significance vanishes during inactivation as the entropy difference returns to 0.

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