Adverse impact of renin-angiotensin system blockade on the clinical course in hospitalized patients with severe COVID-19: a retrospective cohort study.

Sci Rep · 2020 · PMC7680105 · PMID 33219294

Europe PMC DOI

hedged sentence

0.0490

closest p · 1.0× alpha

0.0490

boldest claim

The sentences

borderline significanceP = 0.049actually significant

The rates of other comorbid diseases, including diabetes, tumor, heart diseases, and chronic kidney disease, were not different between the 2 groups (all, P > 0.05), and the Charlson Comorbidity Index (CCI) score was higher in patients treated with ACE-I or ARB, with borderline significance (4.1 ± 1.7 vs 3.3 ± 2.4; P = 0.049).

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