TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.

The highly significant pathological role of TDP-43 is further suggested by a recently proposed diagnostic entity called limbic-predominant age-related TDP-43 encephalopathy (LATE), which predominantly occurs in cognitively impaired oldest-old individuals with co-existing medial temporal amyloid plaques and tauopathy 15 .

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