Systematic review and meta-analysis of surgical drain management after the diagnosis of postoperative pancreatic fistula after pancreaticoduodenectomy: draining-tract-targeted works better than standard management.

Given that an improvement close to significance was also obtained in the three relevant non-significant outcomes at the meta-analysis (grade-C POPF: P = 0.091; POPF-related mortality: P = 0.088; reoperations: P = 0.069; Tables 2 and 3 ) and that the large and very heterogeneous number of studies included in this review is better analyzed by an aggregate analysis than by a meta-analysis, we believe the improvement of the four outcomes observed in patients treated with “draining-tract-targeted” management is clinically relevant.

also in 2,130 other papers

Unfortunately, even with drains, the clinical burden of a POPF may be significant.

also in 13,097 other papers