highly significantp < 0.001
4 D showing a shift in the balance from RANKL towards OPG in cultures with Syndecan-1 deficient osteoblasts that was highly significant at day 7 of the culture ( p < 0.001). mRNA expression studies of the corresponding genes of RANK, RANKL and OPG revealed no striking differences between the genotypes or cell types cultivated separately or in co-culture (see supplemental Fig. 1 ).