The Potential of Plant-Based Bioactive Compounds on Inhibition of Aflatoxin B1 Biosynthesis and Down-regulation of <i>aflR</i>, <i>aflM</i> and <i>aflP</i> Genes.

Analogous treatments performed on the selected 8 extracts identified significant down-regulation of aflM (respectively: 57.5, 17.6, 19.8, 109.6, 18.9, 30.4, 3.7, 11.2 times (all p < 0.001)) and marginally significant down-regulation of aflR (respectively: 9.1, 2.6, 1.9, 6.6, 2.0, 8.6, 1.4, 2.6 times (all 0.01 < p < 0.001)).

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Furthermore, our findings showed a highly significant correlation between the gene expression and the aflatoxin B1 biosynthesis, such that certain doses of the extracts reduced or blocked the expression of the aflR , aflM and aflP and consequently reduced the synthesis of aflatoxin B1.

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