In the case of TAT1 substrate, 14 C‐Trp, we observed its significant accumulation in the distal small intestinal tissue (SI4) in TAT1 KO mice, although there were no significant changes in the TAT1‐LAT4 dKO mice, which showed only a mild trend towards Trp accumulation in SI2 (Fig. 5 E ).
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Tissue-specific deletion of mouse basolateral uniporter LAT4 (Slc43a2) reveals its crucial role in small intestine and kidney amino acid transport.
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