Barely Significant
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Systemic Glycosaminoglycan Clearance by HARE/Stabilin-2 Activates Intracellular Signaling.

Cells · 2020 · PMC7694162 · PMID 33126404

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highly significantno p-value reported
The discovery of this HA-induced conformational change, likely conserved among many Link module superfamily members, is highly significant for understanding how such a structurally simple polysaccharide might activate intracellular signaling.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.