Furthermore, Aβ-containing EVs isolated from PS1 mutant neurons and the CSF of sporadic, late-onset AD patients are neurotoxic to primary rat cortical neurons, whereby there is a highly significant correlation between the EV Aβ 1–42 levels and the induced neurotoxicity [ 29 ].
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Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences.
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