The primary result of TAILOR-PCI was a reduction in first MACE in the genotype strategy arm compared to the standard (clopidogrel) arm, although it narrowly missed statistical significance (HR 0.66, 95% CI 0.43–1.02, p = 0.06).
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The sentences
Additionally, the same data set demonstrated an increasing trend for polypharmacy with increasing age, particularly in the over 75-years-old age bracket.
CES1 catalyses clopidogrel to its inactive metabolite; the variant allele of rs71647871 (p.G143E, MAF ~1%) in CES1 has been associated with increased circulating clopidogrel active metabolite, reduced ex vivo platelet reactivity, and a nonsignificant trend towards decreased MACE [ 121 ].