However, only two of these associations were marginally significant: in high grade (pG3) tumors (OR, 0.54; 95% c.i., 0.29–1.00; p = 0.042), and in PR negative tumors (OR, 0.58; 95% c.i., 0.33–1.01; p < 0.05; Figure 2 ). 2.5.
This modifier effect of SNP309 upon the cancer risk associated with rs150550023 was significant only in endometrial cancer, but a nonsignificant trend was also observed in ovarian cancer, colon cancer, lung cancer in females, and breast cancer, in agreement with the present study [ 30 , 38 ].