a decreasing trendP < 0.05
an increasing trendP < 0.05
Many genera from Firmicutes exhibited an increasing trend ( P < 0.05), including Vagococcus , Roseburia , Enterococcus , Facklamia , Lactobacillus , Faecalibacterium , unclassified Anaerostipes , Lachnobacterium , Coprococcus , Anaerovibrio , Clostridium _ sensu _ stricto , Faecalicoccus , and Staphylococcus , while many genera others exhibited a decreasing trend ( P < 0.05), including Sporosarcina , Oscillibacter , Peptoniphilus , Anaerobium , unclassified Sporobacter , Amphibacillus , Faecalicatena , and Butyrivibrio ( Figure 3 and Supplementary Data 2 ).