A phase III trial of cariporide, an inhibitor of the sodium hydrogen exchanger isoform-1 (NHE-1), in patients undergoing coronary artery bypass graft surgery, found a highly significant reduction in myocardial injury, although this was unfortunately accompanied by a significant increase in cerebrovascular events and mortality [ 132 ].
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Mouse models of atherosclerosis and their suitability for the study of myocardial infarction.
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