highly significantp < 0.001
The PHB ligand FL3 reduces PHB1, SH2D4A, STAT3, and phospho-STAT3 protein levels Comparison of PHB and PHB2 expression in paired HCC tumor and corresponding non-tumor liver tissue of the TCGA-LIHC cohort revealed highly significant overexpression of PHB (fold-difference = 1.78; p < 0.001) but not PHB2 ( N = 50; Fig.