By contrast, GO analysis of genes with down-regulated expression in Gpx5 -/- animals revealed a highly significant functional enrichment of several categories related to sperm development, including “spermatogenesis” (GO: 0007283), “meiotic cell cycle” (GO: 0051321), “spermatid development” (GO: 0007286), and “sperm motility” (GO: 0030317) ( Figure 1d ).
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Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
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