There was an increasing trend in circRASGRF2 levels from ANL tissues to HCC tumor tissues, with a more than 4-fold change from RNA-seq analysis ( Figure 1 E). circRASGRF2 was upregulated in HCC tissues and cell lines We measured circRASGRF2 expression levels in our cohort of 68 HCC patients and their corresponding ANL tissues by quantitative real-time PCR.
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circRASGRF2 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1224 sponge.
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