Lung squamous cell carcinoma and lung adenocarcinoma differential gene expression regulation through pathways of Notch, Hedgehog, Wnt, and ErbB signalling.

Compiling all data, it becomes evident that extremely significant differences exist between gene expression profiles of LUSC and LUAD concerning distinct downstream outcomes of various signalling pathways such as Notch, Wnt, Hh and ErbB.

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Dimensional characteristics of LUSC and LUAD patients—Multiple Factor Analysis (MFA) To confirm the relationship between the groups of variables (expression of downstream effectors chosen from the highly significant modules and lung cancer subtypes) describing the individuals (patients) concerning their clinical characteristics, we applied Multiple Factor Analysis (MFA).

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