Maternal Microdeletion at the <i>H19/Igf2</i> ICR in Mice Increases Offspring Susceptibility to <i>In Utero</i> Environmental Perturbation.

Although there was a nonsignificant trend of gain of methylation at the Igf2DMR1 for methyl deficient H19 ICRΔ2,3 offspring, this epimutation is usually associated with increased Igf2 expression and increased fetal growth. 31 In contrast, methyl deficient H19 ICRΔ2,3 offspring actually exhibited decreased neonatal bodyweight ( Figure 4A ) suggesting the 2 outcomes are likely not linked.

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