Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level.

The authors attribute the potential deleterious effect on functional recovery on a negative interaction with alteplase, as in a previous phase 2 study of IL-1RA conducted prior to widespread use of thrombolysis they had seen a positive trend on outcomes at 90 days.

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