Barely Significant
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Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia.

Sci Rep · 2020 · PMC7718230 · PMID 33277605

Europe PMCDOI
1
hedged sentence
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

marginally significantP = 0.06so close (0.05 < p ≤ 0.1)
None of the adverse events reported by patients (N = 65) was influenced by the patients’ CYP1A2 expression (P > 0.1), and CYP3A4 expression had a marginally significant effect on constipation [47.1% in normal/high CYP3A4 expressers, 71.4% in low CYP3A4 expressers, OR = 3.6 (95%CL = 0.9–14.1), Wald ChiSq = 3.4, N = 65, P = 0.06] (Table 3 ), indicating that patients expressing CYP3A4 at low level tended to report constipation more frequently.

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