did not achieve significanceP < 0.05
After the 2-week treatment period, there was some clustering based on treatment arm which did not achieve significance at P < 0.05 (unweighted, permutational multivariate ANOVA [PERMANOVA] P = 0.08; weighted, PERMANOVA P = 0.07) (see Supplementary Figure 3, Supplementary Digital Content 2, http://links.lww.com/CTG/A460 ).