FLT3 inhibitors in acute myeloid leukaemia: assessment of clinical effectiveness, adverse events and future research-a systematic review and meta-analysis.

A moderate/substantial amount of heterogeneity was present ( I 2 = 68%) and test for subgroup differences was highly significant ( χ 2 = 17.41, p = 0.0006, Fig. 4 ).

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Six trials reported censored data for OS [ 15 , 17 – 21 ] (HR = 0.82, 95% CI 0.73 to 0.93, p = 0.002, Supplementary Figure 10 ), which was in keeping with the results for the uncensored population; however, heterogeneity increased from an I 2 of 32 to 44% and test for subgroup differences was borderline significant.

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