SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress.

Sci Rep · 2020 · PMC7723043 · PMID 33293627

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highly significantno p-value reported

The highly significant co-expression of TMPRSS4 with ACE2 and its relevant role as transmembrane serine protease has enabled us to hypothesize that TMPRSS4 might also be involved in priming the SARS-CoV-2 spike protein.

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