Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome.

World J Gastroenterol · 2020 · PMC7723672 · PMID 33362374

Europe PMC DOI

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closest p · 1.2× alpha

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an increasing trendP = 0.059so close (0.05 < p ≤ 0.1)

In the IBS-D group, patients with a high PBA/SBA ratio had a significantly higher defecation frequency than those with a low PBA/SBA ratio (3.5 [2.5, 4.5] vs 3.0 [1.5, 3.5]; P = 0.038), along with an increasing trend of bowel habit dissatisfaction (70.0 [60.0, 72.5] vs 60.0 [45.0, 70.0]; P = 0.059] and abdominal pain severity (40.0 [30.0, 60.0] vs 30.0 [20.0, 50.0]; P = 0.077).

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