Manipulating the Tumor Microenvironment in Tumor Organoids Induces Phenotypic Changes and Chemoresistance.

The average angle variance between the fibers from both groups was highly significant (p value < 0.0001), suggesting that TGF-β activated the LX-2 cells to successfully remodel and align collagen fibers as seen in ECM dense fibrotic tissues ( Baiocchini et al., 2016 ; Lee and Friedman, 2011 ).

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