Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression.

Clin Epigenetics · 2020 · PMC7724832 · PMID 33298155

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantp < 2e−16actually significant

Again, rs708727 was found to be a highly significant ( p < 2e−16) covariant of all probes, while rs960603 is not.

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marginally significantp = 0.070so close (0.05 < p ≤ 0.1)

We did not observe any association in the control group for any of the 8 CpG sites, and only one probe was found to be significantly associated with Braak staging in the MCI group ( p = 0.038 at cg24503407), and another marginally significant ( p = 0.070 at cg17178900).

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an increasing trendp < 0.1so close (0.05 < p ≤ 0.1)

On top of the effect of allelic dose of rs708727, it also shows an increasing trend of the slope from control to MCI, then to AD (AD vs control, p < 0.1 at 4 probes).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.