Comparative Efficacy of Pharmacological and Nonpharmacological Interventions for Acne Vulgaris: A Network Meta-Analysis.

Fourteen interventions had a significant reduction than placebo (TR+BPO: MD = −21.89, 95%CrI [−28.97, −14.76]; TR+BPO+MTCAM: −22.48 [−34.13, −10.70]; TA+BPO+CP: −20.63 [−33.97, −7.13]; TA+TR+MTCAM: −14.15 [−24.43, −3.97]; TA+TR: −11.42 [−15.91, −7.02]; TA+BPO: −11.10 [−14.61, −7.75]; TR+BPO+OA: −11.84 [−20.52, −2.98]; BPO+MTCAM: −10.44 [−18.52, −2.59]; BPO: −7.84 [−12.42, −3.95]; TA: −7.29 [−10.99, −3.55]; MTCAM: −5.82 [−9.62, −2.96]; CP: −5.08 [−9.26, −1.33]; TR: −4.86 [−7.99, −1.88]; PDT: −4.19 [−6.92, −1.19]) and another three interventions had a borderline significance (TA+MTCAM: −10.17 [−20.13, −0.31]; TR+MTCAM: −7.92 [−15.81, −0.04]; LED: −7.50 [−15.54, −0.17]) (S2 Page 1).

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However, the inconsistency p values were borderline significant, which may impact little on pooled results.

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