We also found that the most highly significant predicted upstream regulators of the identified promoters were hepatocyte nuclear factor 4 alpha (HNF4A) (1.20 × 10 –9 ) and HNF1A (3.42 × 10 –4 ).
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Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis.
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