Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization.

Elife · 2020 · PMC7732340 · PMID 33305736

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As lack of C3 results in fewer CNV lesions in male Vegfa hyper C3 -/- mice compared to male Vegfa hyper mice in a highly significant manner despite inflammasome activation in their RPE/choroids, this suggests that C3 affects CNV lesion formation mainly through inflammasome-independent mechanisms.

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