highly significantP < 0.05
A P value of < 0.05 was considered significant, and a P value of < 0.01 was considered highly significant (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).
A P value of < 0.05 was considered significant, and a P value of < 0.01 was considered highly significant (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).