Naringenin Prevents Propofol Induced Neurodegeneration in Neonatal Mice Brain and Long-Term Neurocognitive Impacts on Adults.

While naringenin administration to propofol-treated mice showed mean time 16.7±1.5 s which was statistically not significant to propofol group (P > 0.05) yet marginally significant as compared to control (P = 0.047).

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An increasing trend in latency time is an indicator of impaired learning and behavior in mice, as caused by propofol exposure.

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The latency time for the control group exhibited a decreasing trend from days 1 to 5 by 100.8, 96.2, 88.6, 82.8 and 76.2 s, respectively.

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