Robust folding of a de novo designed ideal protein even with most of the core mutated to valine.

Proc Natl Acad Sci U S A · 2020 · PMC7739874 · PMID 33229587

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may not be significantno p-value reported

On the other hand, the contribution of local interactions in naturally occurring proteins may not be significant compared with designed proteins.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.