A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?

Despite the significant increases in ACE activity after the treatment with risperidone in FEP individuals with DD genotype, this treatment determined only a nonsignificant trend for higher ACE activity in D allele carrier FEPs as well as for the II genotype FEP subgroup, which showed significantly higher mean ACE activity value relative to the II genotype subgroup of FEP at baseline (i.e., even before treatment) ( Figure 4 ; Table 3 ).

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