Cross-reactive probes on Illumina DNA methylation arrays: a large study on ALS shows that a cautionary approach is warranted in interpreting epigenome-wide association studies.

NAR Genom Bioinform · 2020 · PMC7745769 · PMID 33554115

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highly significantno p-value reported

Strikingly, the OOB probes with a ≥14 bp match that were not significant in the original EWAS (three probes), were highly significant in the OOB EWAS.

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failed to reach significanceno p-value reported

We found however that, some probes that partially match to the C9 repeat failed to reach significance in the EWAS.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.