Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing.

The PKD1 signal could be considered significant upon restricting the search-space and thus multiple-testing correction to the top decile (n=1928) highest expressed genes in the coronary artery tissue data from the GTEX database (accessed November 19, 2019). 18 Prioritization of Nonsignificant Genes From Collapsing Analysis Results by Manual Review and Automated Machine Learning Although no association reached study-wide significance, we hypothesized that within the highly ranked results may be genes in which rare variants do increase the risk of SCAD, but our current study is underpowered to highlight them.

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