Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression.

Front Psychiatry · 2020 · PMC7751613 · PMID 33364984

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a decreasing trendno p-value reported

In short, we could hypothesize that the MTHFR C677T allele is a risk factor for the thinning of CT of MDD patients in the left cACC, ISTC, mOFC, and PCC; the C677T homozygote is a protective factor for increased lOFC CT and also allows the volume of the putamen to manifest a decreasing trend in depression.

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