Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.

Abnormal glucose test ( N = 33), colonic polyps ( N = 29), dysmetabolic syndrome X ( N = 11), and urinary cast ( N = 10) were among the most frequent traits among MC4R carriers that while suggestive, did not achieve significance ( P < 0.001)(Supplementary Table S11 a, b ).

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